PHARMACOGNOSTIC AND ANTI-INFLAMMATORY STUDIES ON THE LEAF OF LUDWIGIA ABYSSINICA RICH. (ONAGRACEAE)
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Ludwigia abyssinica Rich (Onagraceae) is a plant native to South America but now widely distributed in Africa. It has been exploited for its medicinal and economic importance. It is traditionally used for the treatment of a number of ailments such as cough, skin diseases, sores, diarrhoea, rheumatism, constipation, liver diseases and intestinal worm infestations. Aqueous decoction of the leaves is taken orally for its analgesic effect in the treatment of generalized pain in some parts of Africa, and economically, the cooked leaves provide a black liquid that is used for dyeing straw and fibres. L. abyssinica is considered s an ornamental plant because of its showy flowers which are yellow in colour. Evaluation of the fresh, anatomical sections, powdered and extract of the leaves of L. abyssinica were carried out to determine its micromorphological, chemomicroscopic, some physicochemical parameters. The extracts were obtained successively from hexane, ethylacetate and methanol using Soxhlet apparatus, to determine the phytochemical profiles, acute toxicity, and antiinflammatory properties. Microscopical evaluation revealed the presence of anomocytic type of stomata in both adaxial (upper) and abaxial (lower) epidermis with subsidiary cells. The physical constants values were: moisture content (7.00%), total ash value (7.80%), water soluble ash (4.67%), acid insoluble ash (2.33%), ethanol extractive value (17.00%) and water extractive value (19.7%). Phytochemical analysis of the leaf extract (hexane, ethylacetate, and methanol) revealed the presence of alkaloids, tannins, flavonoids, cardiac glycosides, saponins (steroids / triterpenes) and carbohydrate. Thin layer chromatographic analysis visualized with specific reagents confirmed the presence of steroids/triterpenes, flavonoids and other phenolic compounds. The median lethal dose (LD50) via oral route of the extracts was found to be greater than 5000 mg/kg when administered orally in rats. The extracts of L. abyssinica leaf demonstrated significant decrease (p<0.05) against carrageenan viii induced paw oedema in rats, reaching its peak at the 3rd hour and the highest inhibitory value of (28.7, 29.1, 26.7) was shown at the 5th hour for hexane, ethylacetate and methanol extracts at a dose of 1500mg/kg which was higher than the standard, piroxicam (10 mg/kg) having (25.9%). Hexane extract (500-1500 mg/kg) was observed to have the highest activity compared to the other extracts. The results provided basic pharmacognostic standards for the plant and scientific basis for traditional uses of leaves in the treatment of inflammation
Related Project Materials
DESIGN AND CONSTRUCTION OF A BIOMETRIC STUDENTS’ TIME AND ATTENDANCE LOGGING SYSTEM
ABSTRACT
In recent time, there has been high level of impersonation experienced on a daily basis...
EFFECT OF TEACHERS ATTITUDE AND SCHOOL ENVIRONMENTAL FACTORS ON THE ACADEMIC PERFORMANCE OF STUDENT IN BIOLOGY
BACKGROUND OF THE STUDY
Attitude as a concept is concerned with an individual way of thinking, acting a...
HUMAN RIGHTS ABUSES IN THE NIGERIAN PRISON SYSTEM: A CASE STUDY OF NIGER STATE PRISON
ABSTRACT
Prisoners in Nigeria are often perceived and categorized as “outcast”. The belief of many is that, once you are a pr...
ASSESSMENT OF GOVERNMENT’S COUNTER-TERRORISM STRATEGY IN NIGERIA’S INTERNAL SECURITY (2009 – 2013)
ABSTRACT
The research is an assessment of government‟s counter terrorism strategy in Nigeria‟s internal...
FEDERAL CHARACTER PRINCIPLE AND QUOTA SYSTEM IN NIGERIA: A CRITICAL ASSESSMENT OF THE RECRUITMENT EXERCISE IN THE PUBLIC SERVICE
ABSTRACT
The main purpose of this research work was to examine the Federal Character Principle and Quota System in Niger...
EFFECT OF THINK-PAIR-SHARE INSTRUCTIONAL STRATEGY ON SECONDARY SCHOOL STUDENTS’ ACADEMIC ACHIEVEMENT, RETENTION AND SELF-EFFICACY IN FINANCIAL ACCOUNTING IN ABIA STATE
Background to the Study
Business organizations are set up with the principal objectives of creating wealth for the owne...
INDEPENDENCE OF THE JUDICIARY AND PUBLIC PERCEPTION A CASE STUDY OF JUSTICE WALTER ONNOGHEN
Abstract
This study was carried out on independence of the judiciary and public perception. The a case study of Ju...
CORPORATE SOCIAL RESPONSIBILITIES IN HOST COMMUNITIES BY TERTIARY EDUCATIONAL INSTITUTIONS IN SOUTH-SOUTH NIGERIA
Background to the Study
Nations all over the world are concerned about and interested in education, both at national and...
CAPITAL STRUCTURE AND FINANCIAL PERFORMANCE OF LISTED MANUFACTURING FIRMS IN NIGERIA
Abstract
There exists divergence of opinion in literature on the relationship between capital structure and firms finan...
NIGERIA’S IMAGE AND THE PLACE OF THE PUBLIC RELATION IN ITS RECONSTRUCTION
BACKGROUND OF STUDY
Nigeria is one of the famous and great countries that is surrounded with an extreme...
